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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting - a 2 minute Preview of the Experimental Protocol
Franziska Jönsson, Claudia Hagedorn, Florian Kreppel
University Witten/Herdecke, Center of Biomedical Education and Research;
The protocol described here enables researchers to specifically modify adenovirus capsids at selected sites by simple chemistry. Shielded adenovirus vectors particles and retargeted gene transfer vectors can be generated, and vector host interactions can be studied.
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